Objective To investigate the status of alarm fatigue among ICU nurses, analyze its influencing factors, and provide refe-rences for the development of intervention strategies in clinical settings.Methods Convenient sampling was employed to select 252 ICU nurses from three tertiary grade-A hospitals in Guizhou province. Questionnaire surveys were conducted using the general information questionnaire, ICU Nurses′ Alarm Fatigue Questionnaire, and the Compassion Fatigue Measurement. Results The total score for alarm fatigue, compassion fatigue and burnout among ICU nurses was (25.52±5.57), (19.90±5.75), and (20.22±3.28), respectively. Both compassion fatigue and burnout were significantly positively correlated with alarm fatigue among ICU nurses (both P<0.05). Multiple stepwise regression analysis revealed that attitudes towards nursing profession, frequency of setting alarm parameters, professional title, compassion fatigue, and burnout were influencing factors for ICU nurse alarm fatigue (all P<0.05), explaining 43.1% of the total variance. Conclusion Nursing managers should pay close attention to the compassion fatigue and burnout of ICU nurses. It is recommended to optimize staffing arrangements, provide training on medical equipment alarms, enhance nurses′ satisfaction with nursing work, and appropriately set alarm parameters to reduce the level of alarm fatigue among ICU nurses.