Objective To explore the current situation and influencing factors of career compromise of nurses, so as to provide refe-rence for formulating targeted intervention measures to reduce career compromise of nurses.Methods A total of 786 nurses from 5 hospitals in Jiangsu province were selected by convenience sampling method.The General Data Questionnaire, Career Compromise Scale, Spiritual Leadership Scale, Professional Identity Scale and Perceived Overqualification Scale were used to investigate.Results The career compromise score of nurses was (40.15±6.04).Career compromise was negatively correlated with spiritual leadership and professional identity, and positively correlated with perceived overqualification (all P＜0.05).The results of linear regression analysis showed that nurses′ age, highest degree, personal monthly income, spiritual leadership, professional identity and perceived overqualification were the influencing factors of career compromise of nurses, and 50.4% of the career compromise variation was explained.Conclusion The career compromise of nurses was high, and there are many influencing factors. Nursing managers should take various effective measures to help nurses reduce the level of career compromise and further promote the stability and development of nursing team.