Objective To explore the behavior intention and influencing factors of delirium management in PICU nurses based on the theory of planned behavior, so as to provide references for improving the quality of delirium management in PICU.Methods Applying qualitative research methods, 16 PICU nursing staff from 6 grade III-A hospitals in China were selected for semi-structured interview.Data were analyzed and themes were extracted by Colaizzi′s 7-step analysis method.Results A total of 3 themes and 8 sub-themes were identified, including behavioral attitudes (positive attitudes, negative attitudes), subjective norms (increased self-perceived stress, team influence) and perceived behavioral control (insufficient delirium cognition and coping skills, lack of relevant systems and processes, excessive workload, and lack of delirium management ability training).Conclusion PICU nurses have a positive attitude towards delirium management in general, but there are many influencing factors.It is necessary to improve the cognition of nursing staff on delirium, strengthen relevant training, and establish a multidisciplinary team cooperation mechanism to improve the quality of delirium management in PICU.