Objective To explore the mediating role of self-efficacy and social support in the influence of stigma on quality of life, so as to provide theoretical reference for nurses to carry out nursing health education for patients with urostomy.Methods General Data Questionnaire, Social Impact Scale, Social Support Rating Scale, Stoma Self-Efficacy Scale and City of Hope-Quality of Life-Ostomy Questionnaire were used to investigate 298 patients with urostomy who met the inclusion criteria.A structural equation model was constructed.Results The total shame score of urostomy patients was （55.88±9.23） points.The total quality of life score of the patients was （136.36±18.79）.There was a negative correlation between stigma and quality of life in patients with urostomy （P＜0.05）.Self-efficacy and social support mediated the relationship between stigma and quality of life, with the mediating effect accounting for 69.83% of the total effect.Conclusion Overall quality of life of urostomy patients was at a low level.Social support and self-efficacy play a mediating role in the effect of disease shame on quality of life in patients with urostomy.Caregivers cantake positive and effective interventions to reduce patients′ sense of shame,improve patients′ self-efficacy and social support, in order to promote the quality of life of urostomy patients.