Objective To summarize the nursing experience of 6 patients with recurrent/refractory CD30 positive lymphoma under-going autologous stem cell transplantation combined with anti CD30 chimeric antigen receptor T cell infusion.Methods Six patients with recurrent/refractory CD30 positive lymphoma were evaluated for nursing care before treatment, focusing on the care of pretreatment toxicity, cytokine release syndrome, and implantation syndrome.Psychological support and health education were inclu-ded in the entire treatment process.Results Hematopoietic stem cells were successfully implanted in all 6 patients.Persistent CAR30 gene transfer was detected in peripheral blood. Five cases had complete remission and 1 case had partial remission.Five patients developed cytokine release syndrome, all of which were grade I, and no neurotoxicity was observed.At a median follow-up of 20.4 （12.1,34.4） months, all patients survived and maintained their responsiveness.Conclusion Autologous stem cell transplantation combined with anti CD30 chimeric antigen receptor T cell infusion therapy has good tolerance and high activity.Nursing plays an important role in various stages of treatment and in the management of toxic and side effects.