Objective To explore the teaching effect of "5G+smart classroom" based on BOPPPS model in the clinical teaching of thoracic surgery nursing. Methods A total of 90 undergraduate nursing students in thoracic surgery were divided into the control group （43） and the experimental group （47） according to the practice time. The control group used traditional teaching methods. The experimental group adopted a 5G+online+offline+clinical practice "Trinity" smart classroom teaching mode based on the BOPPPS model.The results of practice, independent learning ability and satisfaction with teaching mode were compared between the two groups.Results The scores of practice, independent learning ability of nursing students in the experimental group were significantly higher than those in control group （all P＜0.05）.However, there was no statistically significant difference in teaching satisfaction between the two groups （P＞0.05）.Conclusion The application of "5G+Trinity" smart classroom based on BOPPPS model can improve nursing students′ practice performance, independent learning ability, and improve their clinical teaching effectiveness.