Objective To build a complex diabetes AI management platform based on 5G network, and observe the effect of the application in the management of diabetic patients and the training of primary medical care.Methods A total of 340 discharged patients with type 2 diabetes mellitus （T2DM） were selected.The subjects were divided into observation group and control group by random number table method, with 170 patients in each group.The control group received routine out-of-hospital management of diabetes mellitus, and the observation group received out-of-hospital management based on the complex diabetes AI management platform based on 5G network.The changes of blood glucose control related indicators and self-management behaviors were observed before the intervention and 6 months after the intervention.In addition, 60 nurses were selected in primary hospitals and trained through the platform.The comprehensive ability scores of nurses in primary hospitals were compared before and 6 months after intervention.Results After intervention for 3 months, the fasting plasma glucose, 2-hour postprandial plasma glucose and HbA1c in the observation group were lower than those in the control group （all P＜0.05）.Self-management behavior rating scores in the observation group were higher than those in the control group.After 6 projects were carried out, the scores of theoretical knowledge, practical operation and nursing team building were significantly higher than before （all P＜0.05）.Conclusion The application of the digital medical platform based on 5G network can improve the blood sugar control status of diabetes patients, improve the self-management ability of patients, and promote the ability of grassroots nurses to achieve continuous improvement of nursing quality in the region.