Objective To construct an informatized management plan for perinatal depression and apply it in clinical practice to reduce the occurrence of perinatal depression in pregnant and postpartum women.Methods A total of 375 pregnant and postpartum women were divided into a control group of 185 cases and an intervention group of 190 cases based on admission time.The control group received routine interventions, while the intervention group compiled the best evidence for perinatal depression management, constructed a management plan for perinatal depression, and developed an informatized management system to intervene with pregnant and postpartum women.Pre- and post-intervention comparisons were made between the two groups in terms of depression scores, knowledgebehavior scores related to depression management, and delivery outcomes.Results A total of 157 cases in the control group and 155 cases in the intervention group completed the study.The intervention group showed significantly lower depression scores compared to the control group, with significantly higher scores in knowledge and behavior related to depression management （all P＜0.05）.Additionally, the intervention group exhibited significantly higher rates of natural delivery and exclusive breast feeding compared to the control group （both P＜0.05）.Conclusion The application of informatized management plan for perinatal depression effectively improves the level of perinatal depression in pregnant and postpartum women, thereby maintaining their psychological outcomes.