Objective To evaluate knowledge, attitude and practice (KAP) towards self-management among patients receiving auto-logous skin grafting, and to provide reference for targeted interventions.Methods Based on KAP theory, a KAP questionnaire regarding self-management was developed through literature review, group discussion, Delphi expert consultation, patient survey, item analysis, exploratory factor analysis, and reliability testing.Results The questionnaire included three dimensions:knowledge, attitudes, and practice, totaling 27 items.The results of exploratory factor analysis explained a variance of 66.271%.The scale le-vel content validity index (CVI) was 0.972, and the item-level CVI ranged from 0.824 to 1.000.The overall Cronbach′s α coefficient was 0.934, the split-half reliability was 0.831, and the test-retest reliability was 0.810.Conclusion The questionnaire has good reliability and validity, and can be used to measure KAP on self-management among patients receiving autologous skin graf-ting after further validation.