Objective To explore the trajectories of frailty and their influencing factors among patients with chronic heart failure (CHF), and to provide a reference for targeted intervention.Methods A total of 105 CHF patients were selected by convenience sampling method, and their frailty was assessed at four time points from admission to 6 months after discharge.The trajectory of frailty and influencing factors were determined.Results The median (P25-P75) of frailty score was 2（1,3）,2（0,3）, 1（0,3）, and 1（0,3） at four time points, respectively.Three distinct frailty trajectories were identified: low-level slow decline group （47.6%）, medium-level decline group （18.1%）, and medium-level rise group （34.3%）.Multivariate logistic regression analysis revealed that age, body mass index, the number of co-morbidities, hemoglobin value, cardiac function grading, depression, and physical activity were the influencing factors for the frailty trajectories （all P＜0.05）.Conclusion CHF patients, after inpatient treatment and nur-sing care, show an overall trend of improvement in frailty. There are three frailty trajectories, with significant heterogeneity in the trajectory. Frailty trajectories may offer a way to target individuals in different subgroups, at different periods and with different influencing factors for precise interventions.