Objective To develop and test the reliability and validity of the Stroke Symptom Cluster Scale for stroke survivors, and to provide assessment tool for precise care.Methods Based on the symptom management theory, a draft of the Stroke Symptom Cluster Scale was formed through literature review, Delphi expert consultation and a pilot survey, then 353 stroke patients were surveyed.Item analysis, exploratory factor analysis and reliability analysis were performed to test the reliability and validity of the scale.Results Six principal common factors totaling 35 items were identified by exploratory factor analysis named as physical activity, cognition and speech, sensory perception, swallowing, digestion and excretion, emotional and psychological, accounting for 69.095% of the total variance.The overall Cronbach′s α coefficient was 0.905 and the split-half reliability was 0.728.The content validity index at the scale level was 0.886, and at the item level ranged from 0.920 to 1.000.Conclusion The Stroke Symptom Cluster Scale is valid and reliable for assessing symptom clusters in stroke patients.