Objective To explore the level of medication literacy and its related factors among community-dwelling middle-aged and older stroke survivors, and to provide reference for formulating targeted interventions.Methods A total of 278 community-dwelling middle-aged and older stroke survivors were surveyed using a self-designed demographic questionnaire, the Medication Literacy Questionnaire, the Self-efficacy for Appropriate Medication Use Scale, the Chinese version of the Beliefs about Medicines Questionnaire-Specific, and the Brief 2-Way Social Support Scale.Results The sample scored 4.79±1.75 for medication literacy.Multiple linear regression analysis showed that monthly household per capita income, medication necessity belief, self-efficacy for appropriate medication use, and giving instrumental support were factors affecting medication literacy （all P＜0.05）.Conclusion The medication literacy among community-dwelling middle-aged and older stroke survivors is at moderate level.Community medical staff should provide personalized interventions according to the influencing factors to improve patients′ medication literacy.