Objective To explore the effect of a specialist nurseinvolved stroke risk screening and followup program for inpatients, and to provide reference for primary prevention of stroke.Methods We developed a stroke risk screening mode for patients who were hospitalized in general medical and surgical wards, aged 40 years or older.The first screening was performed by the ward nurse to identify those at highrisk for stroke, then the specialist nurse provided primary prevention interventions for 1 year.Results In September 2021, 3,416 patients at stroke risk were identified, with 513 （15.02%） at high risk, 1,926 （56.38%） at moderate risk, and 977 （28.60%） at low risk.Targeted management was provided for patients with different risk gradings, and the highrisk patients were further treated by the department of neurology.A total of 197 highrisk patients completed 1year followup and presented better control rate of blood pressure and blood lipid, higher exercise participation and selfmanagement ability compared with the baseline assessment before followup （all P＜0.05）.Conclusion The specialist nurseinvolved stroke risk screening mode is beneficial for early detection of patients at risk for stroke, thus to implement primary prevention interventions and reduce the incidence of stroke.