Objective To explore the interrelationships among symptom clusters in children with acute leukemia and to identify bridge symptoms between symptom clusters. Methods A total of 586 children with acute leukemia were selected using convenience sampling, and they were investigated by utilizing the Memorial Symptom Assessment Scale 10-18 （MSAS 10-18）.The network analysis was used to identify the bridge symptoms among the symptom clusters. Results The participants experienced five symptom clusters:oral and skin symptoms, somatic symptoms, self-image disorder symptoms, gastrointestinal symptoms and psychological symptoms.Insomnia （rbS=0.797,rbC=0.090,rbB=73.000） was the bridge symptom with the highest bridge strength, bridge closeness and bridge betweenness in the symptom network, followed by feeling sad （rbS=0.747,rbC=0.075,rbB=30.000）, fee-ling drowsy （rbS=0.745,rbC=0.070,rbB=19.000） and "I don′t look like myself" （rbS=0.612,rbC=0.067,rbB=10.000）. Conclusion The children with acute leukemia undergoing chemotherapy have several bridge symptoms connecting symptom clusters.The bridge symptoms are helpful in simplifying symptom assessment and management, and improving the efficiency of symptom management.It is recommended to conduct longitudinal investigations to understand patterns of symptom cluster changes, and to explore the potential causal relationships and mechanisms among bridge symptoms.