Objective To explore the effect of integrated intervention on oral feeding ability of premature infants in NICU. Methods A total of 104 premature infants hospitalized in NICU were conveniently selected and divided into 2 groups of 52 cases each accor-ding to the time period they were hospitalized.The control group received the routine developmental support nursing.The intervention group received integrated intervention of oral motor intervention, swallowing training and tactile/kinesthetic stimulation on the basis of routine developmental support nursing. Results There were 49 cases in the control group and 47 cases in the intervention group completing the study.The non-nutritive sucking (NNS) scores of premature infants in both groups increased gradually, with NNS scores of the intervention group significantly higher than those of control group on the 7th and 14th day of intervention （P＜0.05 for both）.At the beginning of oral feeding, the oral feeding efficiency, feeding effectiveness and milk intake ratio in the intervention group were significantly higher than those in control group （P＜0.05 for all）.When exclusive oral feeding was achieved, the feeding efficiency and feeding effectiveness of the intervention group were significantly higher than those in the control group （P＜0.05 for both）.The time required for exclusive oral feeding in the intervention group was significantly lower than that in the control group （P＜0.05）. Conclusion The integrated intervention can enhance oral feeding ability, improve oral feeding perfor-mance, and shorten oral feeding process of premature infants.