Objective To explore the intelligent monitoring process for core body temperature throughout the perioperative period, further to provide an empirical scheme for the innovation of perioperative body temperature monitoring. Methods An intelligent wireless body temperature monitoring system based on a wearable wireless body temperature sensor was constructed in the Department of Biliary Surgery and Operation & Anesthesia Center, to continuously monitor the core temperature during the whole perioperative period. Results A total of 3,383 biliary surgery patients were monitored from October 2019 to July 2021 (35.74% vs. 44.37%), lower temperature minimums（36.13℃ vs.35.98℃）, greater temperature drop （0.29℃ vs. 0.47℃）, longer duration of hypothermia（81.00 min vs.165.00 min）, P<0.05 for all. Conclusion By implementing the intelligent core temperature monitoring mode, we extend the intraoperative body temperature monitoring to the whole perioperative period, which reflects the changes of patients′ perioperative body temperature in a real, dynamic and coherent way, and help to guide accurate and individualized perioperative body temperature management.