Objective To investigate the level of financial toxicity in patients with colorectal cancer and analyze its influencing factors. To investigate patient coping strategies to mitigate financial toxicity. Methods A total of 262 patients with colorectal cancer were investigated by General data questionnaire, comprehensive score Scale of Economic Toxicity of patient reported outcome and short answer form of financial toxicity coping strategy. The influencing factors for financial toxicity in colorectal cancer patients were analyzed by multiple linear regression. Results The total score of financial toxicity in colorectal cancer patients was 12.50, among which 215 patients (82.06%) had high financial toxicity. Multiple linear regression analysis showed that， residence, pre-disease employment, family savings, years of illness, clinical stage, stoma, stoma complications, and complications were included in the regression equation (all P<0.05). It can explain 43.1% of the total variation of financial toxicity in patients with colorectal cancer. Most patients adopted a variety of coping strategies in life or treatment to reduce economic toxicity, and the higher the economic toxicity, the easier it was for patients to adopt coping strategies. Conclusion Financial toxicity is common in patients with colorectal cancer, and the level of financial toxicity is high. Health care staff should comprehensively evaluate the financial toxicity level of patients, pay attention to key groups, and educate patients to adopt correct coping strategies; social and management levels should provide key support.