Objective To explore the effect of following-up management by home care platform of patients with coronary stent implantation after discharge. Methods Fifty patients diagnosed with coronary heart disease and received stent therapy in our hospital from June to December 2019 were included in the control group, and 50 patients diagnosed with coronary heart disease and received stent therapy in our hospital from June to December 2020 were included in the observation group. The control group was followed up after routine discharge, and the observation group received PCI home care platform management, including online communication, online popular science education, patient data upload and analysis.The incidence of adverse events, rehospitalization rate, drug use rate, lifestyle change compliance, blood lipid, constitution, blood glucose and blood pressure were compared between the two groups. Results There were statistically significant differences between the two groups in the incidence of adverse events and readmission rate within one year, the use rate of antithrombotic drugs (aspirin, tigritol or clopidogrel), statins, compliance with lifestyle changes, blood lipid, body mass, blood glucose, blood pressure compliance rate and other indicators (P<0.05 for all). Conclusion Home care platform can enhance the communication between patients and medical staff, improve the quality of life of patients as a whole, reduce their economic burden and mental pressure, and avoid excessive waste of medical resources.