Objective To observe the effect of targeted game training on upper limb function, ability to perform activities of daily living (ADL), and rehabilitation training compliance of patients with ischemic stroke. Methods Totally 70 patients with ischemic stroke were randomly divided into a control group of 35 and an experimental group of 35. Both groups were given routine rehabilitation training, while the experimental group was additionally provided with daily 40-minute targeted game training for 8 weeks. Upper limb function, ADL ability, and compliance with rehabilitation training were evaluated and compared at 8 weeks post intervention. Results The above-mentioned parameters in the experimental group were signfiicantly better than the control group (all P＜0.05). Conclusion Targeted game training can significantly improve the upper limb function, ADL ability and compliance with rehabilitation training in patients with ischemic stroke.