Objective To explore the relationship between nurses′ sense of security and turnover intention, and to provide reference for reducing turnover intention and loss of nurses to the workplace. Methods A total of 2,480 nurses from 29 hospitals in Guangdong province were invited to fill out a general data questionnaire, the Sense of Security Scale for Medical Staff, and Turnover Intention Scale. Results They scored 79.62±19.60 on sense of security and 14.13±4.27 on turnover intention.Sense of security was negatively correlated with turnover intention （P＜0.05） and could explain 14.7% of the variance of turnover intention in hierarchical linear model. Conclusion The higher the level of nurses′ sense of security, the lower the turnover intention. Managers should enhance nurses′ sense of security to reduce their turnover intention and stabilize the nursing workforce.