Objective To summarize the best evidences of emergency target blood pressure management for patients with acute aortic dissection,and to evaluate its clinical practice effects. Methods Related domestic and foreign databases and professional association websites were searched using the key words of aortic dissection, aortic aneurysm, blood pressure management, etc., and the best evidences of emergency target blood pressure management for acute aortic dissection were summarized.Based on the Knowledge to Action Framework (KTA), the best summarized evidences were selected and tailored according to the opinions of stakeholders and the current situation of the practice site, and the evidence-based practice scheme was formed after experts consultation.Then the review indicators were developed, the baseline reviews were conducted, and the obstacles and promoting factors were analyzed. Finally, the evidence-based practice scheme was applied to clinical practice from August to September in 2021. Results Totally 24 best evidences were summarized, which was consisted of 7 themes: target value setting, management strategies, disease observation, medical history collection, drug selection, auxiliary examinations, and health education. After the application of the scheme, patients′ target blood pressure and target heart rate reaching rate within 30 min and 60 min were significantly higher than those before the application, emergency medical staffs′ scores on target blood pressure management related knowledge of acute aortic dissection and the nurses′ implementation rate of 7 review indexes were significantly higher than those before the application (P＜0.01 for all). Conclusion The evidence-based practice of emergency target blood pressure management for patients with acute aortic dissection can improve patients′ emergency target blood pressure reaching rate, and increase the implementation rate of relevant knowledge and review indicators by emergency medical staff.