Objective To improve the efficiency of digestive endoscopy and the rate of screening and follow-up in patients at high risk of cancer, and to provide reference for early treatment. Methods We established an outpatient nursing clinic for digestive endoscopy in November 2018 and formulated rules and work process. Tasks of the nursing clinic included making appointment before endoscopy, risk assessment of digestive tract diseases, personalized medication guidance and follow-ups after diagnosis and treatment, and implementation of three-level quality control. Results Since running the nursing clinic for 3 years, we made 25,016 appointments for digestive tract endoscopy, performed 12,560 high-risk cancer screenings, 9,960 Carbon 13 breath tests and 9,435 follow-ups. Patients′ compliance with reexamination and their satisfaction, as well as doctors′ satisfaction have increased year by year. Conclusion Running outpatient nursing clinic for digestive endoscopy enhances outpatient volume, follow-up re-examination of endoscopy, patients′ and doctors′ satisfaction year by year. It optimizes patients′ experience of attendance at outpatient clinic and expands the impact of specialty nursing.