Objective To evaluate the effectiveness of a self-designed computerized management system for full-cycle, closed-loop management of day surgery. Methods A computerized management system was developed to implement full-cycle and closed-loop control of day surgery, including making appointment for examination and surgery, precise verification of surgery, information sharing during the entire surgery among surgeons, nurses and patients, accurately sending disease-related knowledge to patients, conducting follow-ups after discharge on time, and process quality control. Results After applying the computerized management system, the rates of completion of preoperative examination, patient condition assessment, and preoperative visit by an anesthetist, the rates of start-in-time of anesthesia for the first surgery of the day, accurate estimation of operation duration, patient′s awareness of disease-related knowledge, and follow-up after discharge, as well as patient satisfaction were significantly enhanced, whereas the turnover time between two consecutive surgeries was significantly shortened （P＜0.01 for all）. Conclusion Application of the smart management system for full-cycle and closed-loop control of day surgery, can improve work efficiency and patient sa-tisfaction.