Objective To explore the status and influencing factors of self-compassion in patients with chronic heart failure, so as to provide reference for conducting targeted psychological intervention. Methods A total of 293 patients with chronic heart failure were conveniently selected, then they were investigated using the general information questionnaire and the Self-compassion Scale (SCS). Results The SCS score of the participants was (57.99±8.74) points. Multiple linear regression analysis showed that, age, marital status, NYHA cardiac function classification and duration of disease were the main influencing factors of self-compassion in patients with chronic heart failure (P<0.01 for all), which could explain 40.70% of the total variation. Conclusion The self-compassion in patients with chronic heart failure is at a medium level. Medical staff should conduct psychological intervention according to its influencing factors, so as to improve patients′ self-compassion level and enhance their positive psychological strength.