Objective To translate the Health-Related Quality of Life Questionnaire in patients with Home Enteral Nutrition （NutriQoL） into simplified Chinese and to test the reliability and validity in inflammatory bowel disease (IBD) patients. Methods The Chinese version of the NutriQoL was developed through translation and cross-cultural adaptation, then a convenience sample of 185 IBD patients receiving home enteral nutrition were investigated to test the reliability and validity of the questionnaire. Results All 17 items were retained with 14 items in physical functioning domain and 3 items in activities of daily living and social life domain. Exploratory factor analysis identified two factors, accounting for 52.676% of the total variance. The content validity index was 0.96. The Cronbach′s α coefficient was 0.904, the split-half reliability was 0.899, and the test-retest reliability was 0.709. Conclusion The Chinese version of the NutriQoL is a reliable and valid instrument to measure health related quality of life of patients receiving home enteral nutrition.