Objective To explore the impact of nurses′organizational commitment and resilience on their perception toward the essentials of magnetism, and to provide reference for human resource management in nursing. Methods A total of 3 047 clinical nurses working in 4 tertiary general hospitals in Xinjiang Uygur Autonomous Region were surveyed by utilizing the Chinese version of Connor-Davidson Resilience Scale, the Chinese Workers′ Organizational Commitment Scale, and the Essentials of Magnetism Scale. The relationships among the three variables were analyzed. Results The sample scored 64.93±15.73 on resilience, 81.53±16.66 on organizational commitment, and 97.31±21.38 on perception of the essentials of magnetism. Nurses′ psychological resilience was positively correlated with organizational commitment and perception of the essentials of magnetism (r=0.492,0.483, P<0.01 for both), and organizational commitment was also positively correlated with perception of the essentials of magnetism (r=0.561, P<0.01). Nurses′ organizational commitment mediated the relationship between resilience and perception of the essentials of magnetism, with the mediating effect accounting for 55.40% of the total effect. Conclusion The resilience and organizational commitment of nurses are at medium levels, and perception of the essentials of magnetism is between low and moderate level. Organizational commitment plays a role in mediating resilience and work environment. Hospital managers should pay attention to establishing and maintaining nurses′ organizational commitment, stabilizing nursing team, and promoting nurses′ satisfaction, thus to enhance nursing quality. 