Objective To explore the effect of early cardiac rehabilitation nursing based on 5A mode for patients with acute myocardial infarction （AMI） after receiving percutaneous coronary intervention （PCI）. Methods A total of 88 patients with AMI undergoing radial artery PCI were divided into a control group （43 cases） and an intervention group （45 cases） based on the chronological order of admission dates.The control group was given routine nursing, while the intervention group was given early cardiac rehabilitation nursing based on 5A mode. Self-care ability and compliance with rehab exercise measured at 2 weeks and 1 month into the intervention, as well as left ventricular ejection fraction （LVEF）, 6-minute walking distance (6MWD), self-management ability of coronary heart disease measured at 1 month into the intervention and the incidence of cardiovascular adverse events were compared between the two groups. Results LVEF, 6MWD, self-care ability scores, post-PCI rehab exercise compliance, and coronary heart di-sease self-management scores in the intervention group were significantly higher than those in the control group （P＜0.05，P＜0.01）;there were no significant differences in incidence rates of cardiogenic shock, restenosis of coronary artery, arrhythmia and heart failure between the two groups （P＞0.05 for all）.The incidence rate of angina pectoris in intervention group was significantly decreased （P＜0.05）. Conclusion Early cardiac rehabilitation nursing based on 5A mode can increase post-PCI rehab exercise compliance of patients with AMI, improve their cardiac function and exercise tolerance and self-care ability, and improve self- management ability.