Objective To establish a professional team of insulin pump health managers and an inter-disciplinary work model in the hospital, and to provide professional treatment plans, for all diabetes patients on insulin pump therapy in the hospital, and to minimize the risk of insulin pump therapy. Methods A total of 90 patients on insulin pump therapy and hospitalized in south branch of the hospital from December 2018 to June 2019, were assigned into the control group, who received routine insulin pump nursing care. Another 90 counterparts hospitalized in north branch of the hospital from June 2019 to January 2020, were assigned into the intervention group, who were managed with an inter-disciplinary model: a quality control system for intra-hospital insulin pump therapy was established, and a professional team which included endocrinologists, nutrition therapists, and 10 insulin pump health managers, was built to handle insulin pumps used in patients admitted to non- endocrinology departments, and provide professional guidance and education to the patients. Results The blood sugar control level, satisfaction with insulin pump therapy in the intervention group were significantly higher than in the control group ; the incidence rates of such insulin pump adverse events as pump alarming, catheter dislodgement, and hypoglycemia in the intervention group were significantly lower than in the control group （P＜0.05,P＜0.01） . Conclusion The establishment of the insulin pump health managers team could improve blood sugar control level and satisfaction of patients, enhance the expertise of pump handling among nurses working in non- endocrinology departments, and lower the risk of diabetes treatment .