Objective To explore the effect of ginger-separated moxibustion on hypercoagulable state of blood in patients after modified radical mastectomy. Methods Totally, 106 breast cancer patients after modified radical mastectomy were randomized into a control group of 54 and an intervention group of 52. The control group was given routine care, while the intervention group received ginger-separated moxibustion at both sides of acupoints of Xuehai, Sanyinjiao, Zusanli and Taichong from the postoperative day 1 to day 7.Coagulation parameters were measured at 1 day before the surgery and at postoperative day 7 in both groups. Results Compared with the control group, prothrombin time （PT） and activated partial thromboplastin time （APTT） were significantly prolonged, fibrinogen and D-dimer concentrations were significantly reduced in the intervention group （P＜0.05 for all）. No patient in both groups had developed bleeding. Conclusion Ginger-separated moxibustion can effectively improve the blood hypercoagulability of patients after modified radical mastectomy.