Objective To investigate chemotherapy and radiotherapy induced symptoms among lung cancer patients and to describe their self-care practices on alleviating the symptoms. Methods Totally, 302 lung cancer patients were investigated using Therapy-related Symptoms Checklist （TRSC） and Symptom Alleviation: Self-care Methods tool （SA:SCM）. Results The top five self-reported symptoms were fatigue（94.70%）, loss appetite（91.39%）, nausea（78.48%）, hair loss（74.17%） and vomiting（69.21%）; the lung cancer patients also experienced other 29 symptoms besides the 25 symptoms in TRSC. More than 400 symptom alleviation self-care methods were collected, which were classified into 6 aspects includingdiet/nutrition/lifestyle change, mood/body control, biological treatment, herbal treatment, prescribed medicine and others. Conclusion Lung cancer patients encounter serious therapy-related symptoms, and some self-care methods could alleviate the symptoms. Nurses should collect complementary and alternative methods for symptom alleviation based on evidence, so as to manage symptoms effectively, and reduce patients′ symptom distress.