Objective To construct an ICU sedative and analgesic management strategy based on Fault Tree Theory,and eCASH (early Comfort using Analgesia, minimal Sedatives and maximal Humane care) concept, and apply it into clinical practice. Methods We used Fault Tree Theory to figure out the existing problems of sedation and analgesic procedures. Then by referencing to eCASH concept, we established the ICU sedative and analgesic management strategy,which includes unified assessment tools and methods,close monitoring of sedative effect and reevaluation, trainings and exams,implementation of sedation and analgesia nursing measures, tracking the effects of sedation and analgesia.Later, we applied it into practice for six months. Results By the application of ICU sedative and analgesic management strategy,the light sedation rate increased to 57.98%,the incidence rate of delirium reduced to 26.67%, the average mechanical ventilation time descended from 7.63 days to 6.57 days, and the ICU average length of time reduced from 8.94 days to 7.25 days（P＜0.05 for all）. Conclusion With the guidance of eCASH concept, the ICU sedative and analgesic management strategy based on Fault Tree Theory can effectively improve the sedative and analgesic effect of patients undergoing mechanical ventilation.