Objective To investigate the effect of progressive early rehabilitation training for patients developing cardiogenic shock from acute myocardial infarction. Methods A total of 65 patients developing cardiogenic shock from acute myocardial infarction were divided into 2 groups according to the admission order . All the patients were given routine medication and systematic bundle care, and the intervention group additionally received progressive early rehabilitation training. The effect of the two groups was compared. Results In the intervention group, the Barthel Index score, grip values, and the rate of successful weaning from mechanical ventilation at the first attempt were significantly higher than those in the controls; mechanical ventilation time was significantly shorter in the former than in the latter（P＜0.05,P＜0.01）. Conclusion Progressive early rehabilitation training can shorten mechanical ventilation time in patients developing cardiogenic shock from acute myocardial infarction, and raise the rate of successful weaning at the first attempt. The practice also accelerate the recovery of the patient′s muscle strength and activities of daily life, and reduce the incidence of delirium in ICU.