Objective To invent a finger fixation device and observe its application effect in patients at high-risk of extubation. Methods A total of 60 patients admitted to the department of neurology were enrolled and envenly randomized into 2 groups. The intervention group was restrained with the use of the self-made finger fixation device, while the control group was subjected to conventional restraint belts. The chance of extubation and the rate of extubation risk, the skin condition at the restrained site and the acceptance of the restraints by the patients and their families were compared between the 2 groups. Results The chance of extubation and the rate of extubation risk in the intervention group were lower than the control group. The rate of skin injury and redness at the restrained site and the acceptance of the restraints by the patients and their families had significant differences between the 2 groups（P＜0.05，P＜0.01）. Conclusion The application of the self-made finger fixation device can lower the extubation chances and rate of extubation risk for patients at high-risk of extubation, reduce redness and injury of skin at the restrained sites, and improve the acceptance of restraints by the patients and their families.