Objective To establish a case manager guided nursing process in gynecological day surgery,so as to provide safe and convenient treatment and nursing services for patients. Methods Totally 300 patients undergoing gynecological day surgery were randomized into an experimental group and a control group, with 150 patients in each group.The control group was given routine nursing for gynecological day surgery, while the experimental group accepted case manager guided nursing process in gynecological day surgery. Results The temporary cancellation rate, hospitalization expenses, transfer rate, post-discharge complication rate, emergency visiting rate within 72 hours and unplanned readmission rate within 7 days of the experimental group were significantly lower than those of the control group （P＜0.05,P＜0.01）, while patient satisfaction was significantly higher than that of the control group （P＜0.01）. Conclusion Practice of the case manager guided nursing process in gynecological day surgery, can effectively shorten patients′ diagnosis and treatment time, alleviate their economic burden, reduce wasting of medical resource, promote patients recovery earlier, and improve their satisfaction.