Objective To explore the application effect of the mobile home care platform in the transitional care of patients with osteoporotic thoracolumbar fractures. Methods Totally 119 inpatients with osteoporotic thoracolumbar fractures were randomized into a control group (n=58) and an experimental group (n=61). The control group accepted traditional transitional care, while the experimental group accepted the continued care based on the mobile home care platform.The effect was evaluated 3 months after the intervention. Results Three months after the intervention, there were significant differences in the self-efficacy score, patients′ satisfaction, the pain score and the bone density level between the two groups (P＜0.05,P＜0.01). Conclusion The transitional care based on the mobile home care platform can increase self-efficacy for patients with osteoporotic thoracolumbar fractures, promote the improvement of their clinical symptoms, and it is conducive to patients′ rehabilitation.