Objective To explore the application effect of a virtual management mode based on "cloud outpatient service" in the self-management of discharged patients with type 2 diabetes, and to provide new programs for transitional care. Methods Totally 96 discharged patients with type 2 diabetes were randomized into an experimental group and a control group, with 48 patients in each group.The control group accepted individualized diagnosis, treatment and health guidance in outpatient department, and they were followed-up using phone every 2 weeks.While the experimental group was managed using App online consultation and "cloud outpatient service" video inquisition.The glucose metabolism indicators and self-management behavior of the two groups before discharge, 3 and 6 months after discharge were mearsured. Results When compared with the 2h postprandial blood sugar and the score of self-management behavior between the two groups, there were significant group effect, time effect and group by time effect (P＜0.05,P＜0.01), and the standard reaching rate of glycosylated hemoglobin in the experimental group was significantly higher than that of the control group (P＜0.05). Conclusion Conducting the management mode based on "cloud outpatient service" in diabetes patients can improve patients′ blood sugar, and enhance their self-management behavior.