Objective To explore the status and influencing factors of Acute Stress Disorder (ASD) in stroke patients. Methods Three hundred and forty-nine hospitalized patients with stroke were investigated using Stanford Acute Stress Response Questionnaire (SASRQ). Results A total of 163(46.70%) patients developed ASD. Logistic regression analysis results showed that, patient′s personality, whether existing hemiplegia and swallowing dysfunction were the main influencing factors of ASD in stroke patients (P<0.05, P<0.01). Conclusion The incidence rate of ASD in stroke patients is high, the patients with introverted personality and presenting hemiplegia and swallowing dysfunction are prone to suffer ASD. Medical staff should provide individual treatment and predictive care for high-risk patients in time, in order to prevent patients developing ASD.