Objective To explore the effects of multidimensional management model based on informatization on Chemotherapyinduced Nausea and Vomiting（CINV）and quality of life. Methods Totally106 cancer patients undergoing moderately or highlyemetogenic chemotherapy from April to September 2017 were taken as a control group, who received routine chemotherapy nursing，while another 58 cancer patients undergoing moderately or highly emetogenic chemotherapy from October 2017 to April 2018 were selected as an intervention group, who were given whole course management using multidimensional management model based on informatization and participated by physicians, nurses and patients. Results The degree of nausea during the 1st to 5th chemotherapy cycles and the degree of vomiting during the third to fifth chemotherapy cycles of the intervention group were significantly milderthan those of the control group(P<0.05,P<0.01), and the Functional Living IndexEmesis (FLIE) score during the 2nd to 5th chemotherapy cycles were significantly higher than those of the control group (P<0.05,P<0.01). Conclusion The multidimensional management model based on informatization and participated by physicians, nurses and patients is conducive to alleviating CINV for cancer patients, and improving their quality of life.