Objective To explore the effect of integrated oral motor interventions on neurobehavioral development in preterm infants. Methods A total of 144 preterm infants hospitalized in neonatal intensive care unit were randomized into 3 groups: the control group (n=44) was given routine developmentally supportive care, the OMIs group (n=42) additionally received Fucile′s oral motor interventions, and the IOMIs received integrated oral motor interventions. Neurobehavioral development was measured using the Neonatal Behavioral Neurological Assessment (NBNA) at the 3rd, 7th and 14th day after admission and compared among the 3 groups. Results There were no statistically significant differences in the total NBNA score and the dimension scores among the 3 groups at the 3rd and 7th day after admission (P>0.05 for all). On the 14th day, the IOMIs group had higher total NBNA score and dimension scores of general situation and original reflection than the control group(P<0.05 for all), and also had higher total NBNA score and score of original reflection than the OMIs group (P<0.05 for both). Conclusion The integrated oral motor interventions can effectively promote neurobehavioral development in preterm infants at the 14th day of admission.