Objective To summarize best evidence regarding prevention and management of medical device related pressure injuries, and to provide references for clinical nurses. Methods By referencing to evidence-based methods, we searched electronic databases and professional websites to retrieve publications regarding prevention and management of medical device related pressure injuries. Then we used the Appraisal of Guidelines for Research and Evaluation instrument (AGREE Collaboration, 2012), the 2014 JBI evidence pre-grading, and the evidence recommendation system to evaluate the quality of the literature and identify the level of evidence. Results A total of 4 guidelines and 1 evidence summary were retrieved, and 22 pieces of evidence categorized into risk assessment, selection and wearing of medical devices, evaluation of skin and medical devices, and preventive measures, were summarized. Conclusion Clinical nurses should give heed to the prevention and management of medical device related pressure injuries, and select relevant evidence for application according to specific clinical situations and patient preferences.